PAART Study

Project Status: Current
People Involved: Limin Mao, John de Wit
Research Areas: HIV & Sexual Health Risk & Risk Reduction
Funding Agency: Gilead Science, Department of Health and Human Services, State Government of Victoria, ACT Health, Australian Government Department of Health
Non-Staff Involved: Krista J. Siefried, Stephen Kerr, Lucette Cysique, Thomas Gates, John McAllister, Andrew Carr (St Vincent's Centre for Applied Medical Research); Anthony Maynard (NAPWHA),
Partners / Collaborators: National Association of People Living with HIV AustraliaSt Vincent’s Centre for Applied Medical Research

PAART (Predictors of Adherence to Antiretroviral Therapy) is an open, prospective clinical observational cohort, established in October 2013. Patients are recruited from hospital outpatient clinics, sexual health clinics and high HIV-caseload general practices. HIV-positive patients who were on ART and had achieved viral suppression within the past 3 months were eligible for enrolment. Using the Computer Assisted Self-Interview (CASI) technology, each participant self-completes a questionnaire onsite at baseline, and at 12 and 24 months. Also, site clinical coordinators extract data from patient clinical records and complete an electronic case report form though CASI at baseline and every 6 months.

Over 500 patients have already been enrolled from 17 clinical sites nationwide into the cohort. A two-year follow-up from baseline recruitment is currently underway. Data from this observational clinical cohort will provide much needed real-life (i.e., outside of strictly planned clinical trial settings) information on key facilitators and barriers at both patient and clinical system- levels that predict continuous ART use, maintenance of high levels of ART adherence and sustained retention in HIV clinical care in Australia.

The overall objective of this study is to critically strengthen the Australian HIV response by contributing novel knowledge, improved understanding and an innovative ART outcome monitoring mechanism (a combination of patient- and clinician- reported clinical outcomes) to promote effective engagement along the HIV treatment and care continuum. The project has the potential to complement current ART clinical monitoring systems (e.g., AHOD and ACCESS) in providing much needed understandings of patient and clinician interactions right from the moment of HIV treatment initiation to a life-long process of continued engagement with HIV clinical treatment, care and support in Australia.


Publications

Siefried, K.J., Mao, L., Kerr, S., Cysique, L.A., Gates, T.M., McAllister, J., Maynard, A., de Wit, J., Carr, A. on behalf of the PAART study investigators. (2017) Socioeconomic factors explain suboptimal adherence to antiretroviral therapy among HIV-infected Australian adults with viral suppression. PLoSOne 12 (4): e0174613. DOI: 10.1371/journal.pone.0174613